Multipotent Mesenchymal Stromal Cells Express FoxP3
نویسندگان
چکیده
منابع مشابه
Multipotent Mesenchymal Stromal Cells for Autoimmune Diseases.
SUMMARY: Multipotent mesenchymal stromal cells (MSC) are under consideration for the treatment of autoimmune disease (AD) based on their in vitro antiproliferative properties, efficacy in animal models, apparent low acute toxicity, and the early positive anecdotal outcomes in human acute graft versus host disease. Phase I/II clinical trials are under way in multiple sclerosis and Crohn's diseas...
متن کاملMultipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors?
The clinical use of bone marrow derived multipotent mesenchymal stromal cells (BM-MSCs) in different settings ranging from tissue engineering to immunotherapies has prompted investigations on the properties of these cells in a variety of other tissues. Particularly the role of MSCs in solid tumors has been the subject of many experimental approaches. While a clear phenotypical distinction of tu...
متن کاملUltrastructural features of human adipose-derived multipotent mesenchymal stromal cells.
Multipotent mesenchymal stromal cells (MMSCs) are plastic-adherent cells with a well-established phenotype. Equine, but not human, adipose MMSCs have been characterized ultrastructurally. The purpose of our study was to evaluate ultrastructurally the adipose-derived human MMSCs. Cell cultures were prepared from human lipoaspirate. The flow cytometry evaluation of surface markers of cultured cel...
متن کاملRegulation of Immunity via Multipotent Mesenchymal Stromal Cells
Immune cells responsible for inflammation development are involved in tissue damage caused by wounding and various pathologies. Control of immune cell activation could be of significant benefit for regenerative medicine and the treatment of patients with autoimmune and degenerative diseases. It is a proven fact that MCSs (multipotent mesenchymal stromal cells) are capable of suppressing immune ...
متن کاملEndogenous collagen influences differentiation of human multipotent mesenchymal stromal cells.
Human multipotent mesenchymal stromal cells (hMSCs) are multipotent cells that, in the presence of appropriate stimuli, can differentiate into different lineages such as the osteogenic, chondrogenic, and adipogenic lineages. In the presence of ascorbic acid, MSCs secrete an extracellular matrix mainly composed of collagen type I. Here we assessed the potential role of endogenous collagen synthe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Immunotherapy
سال: 2011
ISSN: 1524-9557
DOI: 10.1097/cji.0b013e318217007c